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found that the protective effect of dulaglutide on learning and memory impairment might be the result of reducing the hyperphosphorylation of tau and neurofilament proteins in a PI3K/AKT/GSK3 signaling pathway-dependent manner (48)

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In summary, supplementing GLP-1 RA-induced weight loss with simultaneous blockade of GDF8 and ActA can increase lean mass and muscle, yielding increased fat loss and widespread metabolic benefits and thus improving the quality and functional response to GLP-1 RA-induced weight loss

Subjects from the SUSTAIN 6 study treated with sc semaglutide had a 26% reduced risk of a cardiovascular events compared with the risk among individuals who received a placebo [57]

Most side effects are: Mild to moderate in severity Digestive in nature (nausea, constipation, or diarrhea) Temporary, resolving within days to weeks Manageable with proper dosing and supportive strategies Serious side effects are rare but can include pancreatitis, gallbladder issues, or allergic reactions