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Effects of liraglutide on myocardial function after cardiac surgery: a secondary analysis of the randomised controlled GLOBE trial

GLP-1R agonists consistently cause a reduction in muscle mass (usually measured as lean mass or fat-free mass) as part of their overall weight-loss effect

Clinicians may also review strength, activity, and protein intake when lean-mass preservation is a concern

44 Excessive ROS can inhibit IRS1 activation by activating inflammation-related protein kinase C, inhibitor kappa B kinase (IKK), c-Jun N-terminal kinase (JNK), and p38 MAPK, thereby aggravating IR, 45 creating a vicious cycle

GLP-1 is short for glucagon-like peptide-1 agonist