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Nissen, who serves as study co-chair of SURMOUNT-MMO, notes that the exclusion of patients with diabetes will avoid confounding of results by favorable outcomes due to tirzepatides antidiabetic effects

[67] studied a cohort of over 400,000 T2DM patients above the age of 65 and found that DPP-4i were associated with a 21% decrease in the risk of MACEs (including myocardial infarction and ischemic stroke) with a 46% overall decrease in risk of all-cause mortality

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Experimental procedures included surgery models such as subdiaphragmatic vagal deafferentation (SDA), specific ablation of the area postrema (AP), and paraventricular nucleus (PVN) lesions, all of which were conducted on Sprague-Dawley (SPDR) rats