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D., Vallaster, M., Mehl, U., Brunner, S., David, R., Fischer, R., Krieg, L., Hirsch, E., Huber, B., Nathan, P., Israel, L., Imhof, A., Herbach, N., Assmann, G., Wanke, R., Mueller-Hoecker, J., Steinbeck, G., & Franz, W

J Mol Biol 432: 1347-1366, 2020

The result is a molecule with a plasma half-life of approximately 155 to 183 hours (~7 days) enabling once-weekly dosing in research models and clinical protocols while retaining potent, selective activation of the GLP-1 receptor across multiple tissue types including the pancreas, gastrointestinal tract, brain, kidney, liver, and cardiovascular system

Tau protein interacts with tubulin to stabilize the structure of neuronal microtubules through its isoforms and phosphorylation, supporting neurite differentiation and growth, as well as transporting motor proteins along the axons (29, 34)

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