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Proc Natl Acad Sci U S A (2013) 110(22):906671.10.1073/pnas.1219451110 197 HofmannAFBorgstroemB
The risk of papilledema was reduced across all time points, with the lowest RR at 3 months (RR: 0.69 (95% CI: 0.55, 0.86)), and the effect remained significant through 24 months
otherwise, skip the missed dose
Most patients experience modest hunger increase during weeks 3-6 of the wean, which typically plateaus rather than continuing to spike
These medications are contraindicated per the FDA boxed warning when there is a personal or family history of medullary thyroid carcinoma (MTC) or MEN 2
