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Int J Epidemiol 44:82736

242244 By potentially mitigating the detrimental effects of oxidative stress, inflammation, and cellular senescence, GLP-1 RAs can contribute to preserving both the functionality and number of stem cells, thus fostering a healthier cellular environment that supports regenerative processes

After propensity score matching the GLP-1 cohort (n=45,704) included 35,753 (78.2%) women and 7,852 (17.2%) men with a mean age of 61.1, while the OWLD cohort (n=45,704) included 35,732 (78.2%) women and 7,815 (17.1%) men with a mean age of 61.0

Dual GLP1 and GIP agonists Tirzepatide is a once weekly, subcutaneous, unimolecular dual RA (GLP-1 and GIP) which has comparable GIP receptor binding affinity to native GIP and 5 times lower GLP-1 receptor affinity than that of native GLP-1