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While these effects are beneficial in metabolic regulation, they also underline the most reported adverse effects, namely, nausea, vomiting, and diarrhea, all gastro-intestinal related, particularly during the initiation or rapid dose escalation of therapy

doi: 10.1039/C9RA02977J

Viridian: C.

221,222 Likewise, inhibiting mTOR, particularly with the drug rapamycin, extends lifespan and delays the onset of age-related illnesses in several species
