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For diabetes and obesity, the benefits of GLP-1s depend on long-term use

The exact number of doses a patient needs may vary depending on their specific treatment plan and any adjustments made by their healthcare provider

[13] [14] Patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 should not receive GLP-1 medications due to the theoretical risk of thyroid C-cell tumors
It may also increase appetite and lead to poor food decisions

ADA/EASD Consensus Report 2022 Why Feeling Nothing Yet Is Normal A widespread misconception is: If I dont feel it, its not working. But semaglutide is not an instant medication