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For context, a 2023 report on non-serious events in breastfed infants of mothers not taking medication found that 2.8% of healthy infants experienced poor feeding and 3.9% had diarrhea [45]

The use of XIGDUO XR for this indication is also supported by evidence from adequate and well-controlled trials of metformin HCl immediate-release tablets in adults with additional data from a controlled clinical trial using metformin HCl immediate-release tablets in pediatric patients 10 to 16 years old with type 2 diabetes mellitus, and pharmacokinetic data with metformin HCl extended-release tablets in adults [see CLINICAL PHARMACOLOGY and Clinical Studies ]