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Information on the use of medications that may promote weight gain during the time of semaglutide treatment was collected as well

Diabetes Care, 46 (2), 384390

These symptoms make sense biologically, based on how GLP-1 drugs can engage and modulate dopamine-producing neurons in the brains ventral tegmental area (VTA), a region that influences peoples moment-to-moment motivation for motor, cognitive, and complex executive behavior, the doctors wrote

Antagonism of glutamatergic NMDA and mGluR5 receptors decreases consumption of food in baboon model of binge-eating disorder

Tirzepatide (Mounjaro, Zepbound) adds GIPR agonism to GLP-1R, producing approximately 22.5% weight loss