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Weight-loss outcomes by dose from the PIONEER program: 3 mg daily: Mean weight loss: 2.0% at 26 weeks Placebo-adjusted: 0.1% (not statistically significant) Clinical interpretation: starter dose only, no meaningful weight effect 7 mg daily: Mean weight loss: 2.3% at 26 weeks Placebo-adjusted: 0.4% Clinical interpretation: modest weight effect, primarily a glucose-control dose 14 mg daily: Mean weight loss: 4.4% at 26 weeks Placebo-adjusted: 2.3% Clinical interpretation: maximum oral dose, moderate weight effect For context, lifestyle intervention (diet and exercise) typically produces 3% to 5% weight loss in clinical trials

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Our approach blends the expertise of our specialists, state-of-the-art technology, and compassionate care to provide effective and comfortable treatment for women with uterine fibroids, including UFE