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Melatonin has been reported to bind KEAP1, thereby disrupting this interaction and permitting NRF2 to translocate to the nucleus where it can activate antioxidant response element (ARE)-driven gene expression (25, 41, 62, 63)
Agents 56:106054
Extrinsic signaling pathways are activated via cell surface death receptors, including Fas, TRAIL and TNF- signaling
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Molloy AM, Pangilinan F, Mills JL, et al
