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Additionally, the efficacy of the tested therapy depended on the dose of the anti-VEGF agent: lower doses of anti-angiogenic agent were superior to higher doses in augmenting the infiltration of tumor with CD4+ and CD8+ T-cells and in polarizing tumor-associated macrophages, from immunosuppressive M2 towards immunostimulatory M1 phenotypes

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Cho, Y.H., Giese, K.P., Tanila, H., Silva, A.J