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These results suggest that MTHFR deficiency coupled with a low-quality high-fat diet may increase the risk of developing non-alcoholic fatty liver disease (NAFLD) due to disrupted methylation capacity, lipid metabolism, and inflammatory responses [24]

Short-chain fatty acids matter most here: butyrate in particular fuels the cells lining the colon and helps reinforce the tight-junction proteins that control what passes between cells (Koh et al., 2016)

Learn about the effects of coffee intake on bone mineral density, risk of osteoporosis, and risk of fracture

The CellROX TM system is another method that is currently under investigation in the clinical setting [62,63]

J Biol Chem 35: 29-41