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This distinguishes it from GLP-1 medications, which in some patients have been associated with significant lean mass reduction alongside fat loss
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The peptide has shown an excellent safety profile with minimal reported side effects, partly because it is a naturally occurring fragment of a human peptide

10.1016/j.ejpb.2013.09.014 CrossRef Google Scholar View reference in article 56 KhafagyE.-S.KameiN.Takeda-MorishitaM
