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Adding supplemental vitamin C in the form of ascorbic acid, the equivalent form of vitamin C found naturally in foods, will increase blood levels further, but natural absorption of vitamin C above the intake of about 200 mg decreases sharply with increasing doses by as much as 50%

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HCV polyprotein is processed into nucleocapsid (C, core protein), envelope 1 (E1) and envelope (E2), viroporin protein (p7), and six nonstructural proteins including NS2 (cysteine protease), NS3 (serine protease and RNA helicase, providing enzymatic functions for replication and evasion of innate immune responses), NS4A (NS3 protease cofactor), NS4B, NS5A (RNA-binding site essential for replication and assembly, interacting with the HCV replication complex), and NS5B (RNA-dependent RNA polymerase, RdRp) [711]