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In addition, the characteristics and interactions of human CNS diseases are too complex to construct complete mechanistic models in vitro, but only by constructing animal models of such diseases[194]
Interestingly, clinical studies used morning IV infusions and still observed delayed sleep-enhancing effects suggesting DSIP's mechanism is regulatory rather than acutely sedating
The published human trials cover a handful of studies and fewer than three dozen subjects
HLA-G haplotypes are differentially associated with asthmatic features
The final sample comprised 331 patients (160 males and 171 females), aged 6.5 to 52 years (M = 18.19, SD = 8.72)
