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183 Notably, stimulation of the PI3K/AKT pathway was found to antagonize PTEN function to ameliorate LPS-mediated intestinal epithelial barrier disruption

(6) Chi Zhang, Yun Xie, Haicheng Chen, Linyan Lv, et al (2020) FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice Aging (Albany NY)

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Human evidence is limited to early-phase ulcerative colitis trial work under the PL 14736 designation