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Stroke, particularly ischemic stroke, is a leading cause of adult disability and death worldwide, characterized by the sudden interruption of cerebral blood flow and the subsequent cascade of energy failure, excitotoxicity, oxidative stress, and neuronal death [8487]

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Specifically, while adult KI mice exhibited robust anxiety-like behaviors within the first 48 h following SDS, these effects were largely attenuated one week later, with only limited and parameter-specific alterations remaining