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Apr 28 2020;35(4):950-957

10.1016/j.eurpolymj.2022.111648 14 ChenH.WangB.LiJ.XuJ.ZengJ.GaoW.et al (2023a)

doi: 10.1111/cen.13915 128 WebbSMCrespoISantosAResminiEAulinasAValassiE

However, in contrast to a relatively small number of drugs with glucuronidation as primary elimination pathway, for a vast majority of drugs, glucuronidation often occurs as a secondary step after the primary metabolites are produced by phase I reaction such as hydrolysis, hydroxylation, dealkylation, etc

Evidence for gut microbiota involvement in anxiety disorders is consistent across human studies and strongly supported by preclinical mechanistic data, with therapeutic interventions showing early promise in randomized controlled trials, yet still requiring a large-scale validation
