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In November 2006, the first patient proved to have a significant cavitated Class V caries lesion requiring resin-modified glass ionomer restoration

TB-500 activates early-phase repair signals: Akt-mediated cell survival, actin-driven cell migration, and MMP-mediated matrix remodeling to clear debris

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Furthermore, the approved drugs suffer from disadvantages and/or adverse reactions and search for new effective iron chelators with low toxicity is still an important objective 17,18