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Esta accin, reforzada por sus efectos sobre el cerebro, reduce el apetito y la ingesta de alimentos.El GIP, por su parte, estimula tambin la liberacin de insulina en presencia de glucosa y desempea un papel complementario en la regulacin del metabolismo energtico

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Finally, we demonstrate that in mice, both the efficacy and tolerability of GLP1R agonists vary with the phase of the estrous cycle, being highest during proestrus (when estrogen levels peak) and lowest in diestrus (low estrogen levels)
