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The most frequent adverse effects are gastrointestinal and dose-related: Nausea, vomiting, diarrhoea, constipation, and abdominal discomfort - Typically worst during dose escalation and often resolve or attenuate with continued treatment and slower titration

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Effect of the glucagon-like peptide-1 receptor agonist liraglutide, compared to caloric restriction, on appetite, dietary intake, body fat distribution and cardiometabolic biomarkers: a randomized trial in adults with obesity and prediabetes

The recent surge in popularity of medications like Wegovy (semaglutide) and Zepbound (tirzepatide) (tirzepatide) has changed the landscape of medical weight loss

Understanding these predispositions should inform a collaborative discussion with your provider about dosing strategy, expected timeline to response, and whether combination approaches align with your genetic profile