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The Kaplan-Meier curve, Gehan-Breslow-Wilcoxon and log-rank test were employed to assess the impact of individual variables on prognosis

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and severe episodes (i.e., episodes for which the patient required assistance from another person or that resulted in seizure or loss of consciousness) [] Postural hypotension: Symptoms of hypotension, orthostatic hypotension, postural dizziness, dehydration, syncope, or presyncope [] Gastrointestinal upset: Any events of abdominal discomfort, abdominal pain, nausea, vomiting, excess flatulence, abdominal fullness, and diarrhea can be considered GI upset Other adverse events: Any unexpected medical problem was recorded during treatment with a drug or other therapies which may be mild, moderate, or severe and may be due to other than drug or therapy

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