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As the duration of GLP-1R agonist action is extended with peptides like albiglutide, dulaglutide, long-acting release exenatide, or liraglutide (half-lives of 12 hours to several days), the impact on blood glucose levels is enhanced as insulinotropic action and activity to reduce glucagon become more prominent than the effect on gastric emptying

Liu W, Ye P, OKusky JR, DErcole AJ (2009 Oct) Type 1 insulin-like growth factor receptor signaling is essential for the development of the hippocampal formation and dentate gyrus

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