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Keywords: GLP-1 receptor agonists, Neuroprotection, Synaptic plasticity, Central nervous system, Neurodegenerative diseases Graphical abstract Introduction GLP-1 receptor agonists (GLP-1RAs) are well-established treatments for type 2 diabetes mellitus (T2DM) and obesity, providing effective glycemic control, weight loss, and cardiovascular benefits [[1], [2], [3]]

Trying other diabetes medications like metformin first may be required before starting Ozempic treatment

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There were isolated reports of suicidal ideation, so patients should be monitored closely during the early weeks of treatment

This overlap actually helps bridge the transition period, preventing a complete loss of appetite suppression while the semaglutide builds to therapeutic levels