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In human iPSC-derived dopaminergic neurons from PD patients with SNCA mutations, exendin-4 restored insulin signaling, improved mitochondrial function, and reduced -synuclein aggregation via PI3K/Akt/mTOR activation (26)

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Prevent muscle loss by consuming 1.0-1.6g protein per kg body weight daily, doing resistance training at least twice weekly, avoiding rapid weight loss (stick to 1-2 pounds per week), and ensuring adequate calorie intake

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