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combining glp-1 receptor agonist with dpp-4 inhibitor not recommended guideline Complete pharmacology and pharmacotherapy of inhibitors in bullet points for easy understanding: DPP-4 Inhibitors –Summary 1. Drug Names (Generic / Brand) Sitagliptin – Januvia Saxagliptin – Onglyza Linagliptin – Tradjenta Alogliptin – Mechanisms of dipeptidyl peptidase‐4 (DPP‐4)

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A previous study indicated that treatment with the GLP-1 agonist liraglutide (subcutaneously at a dose gradually titrated from 0.6 to 3 mg) in bipolar and mood disorder depression patients could result in an improvement in cognitive function and an alleviation of depressive pathological symptoms ( Considering this evidence, increasing neurogenesis in the brain through the GLP-1 pathway may provide a novel approach for improving depressive-like behavior in patients with depression

combining glp-1 receptor agonist with dpp-4 inhibitor not recommended guideline Complete pharmacology and pharmacotherapy of inhibitors in bullet points for easy understanding: DPP-4 Inhibitors Summary 1. Drug Names (Generic / Brand) Sitagliptin  Januvia Saxagliptin  Onglyza Linagliptin  Tradjenta Alogliptin  Mechanisms of dipeptidyl peptidase4 (DPP4)

doi:10.1007/s11064-017-2250-8 191

combining glp-1 receptor agonist with dpp-4 inhibitor not recommended guideline Complete pharmacology and pharmacotherapy of inhibitors in bullet points for easy understanding: DPP-4 Inhibitors Summary 1. Drug Names (Generic / Brand) Sitagliptin  Januvia Saxagliptin  Onglyza Linagliptin  Tradjenta Alogliptin  Mechanisms of dipeptidyl peptidase4 (DPP4)

The remaining authors declare no competing interests or conflict of interest

combining glp-1 receptor agonist with dpp-4 inhibitor not recommended guideline Complete pharmacology and pharmacotherapy of inhibitors in bullet points for easy understanding: DPP-4 Inhibitors Summary 1. Drug Names (Generic / Brand) Sitagliptin  Januvia Saxagliptin  Onglyza Linagliptin  Tradjenta Alogliptin  Mechanisms of dipeptidyl peptidase4 (DPP4)

This is referenced in Ayurveda as a herbal medicinal method, detailing the diseases of kapha and pitta [35]

combining glp-1 receptor agonist with dpp-4 inhibitor not recommended guideline Complete pharmacology and pharmacotherapy of inhibitors in bullet points for easy understanding: DPP-4 Inhibitors Summary 1. Drug Names (Generic / Brand) Sitagliptin  Januvia Saxagliptin  Onglyza Linagliptin  Tradjenta Alogliptin  Mechanisms of dipeptidyl peptidase4 (DPP4)

10.2337/db13-1654 37

combining glp-1 receptor agonist with dpp-4 inhibitor not recommended guideline Complete pharmacology and pharmacotherapy of inhibitors in bullet points for easy understanding: DPP-4 Inhibitors Summary 1. Drug Names (Generic / Brand) Sitagliptin  Januvia Saxagliptin  Onglyza Linagliptin  Tradjenta Alogliptin  Mechanisms of dipeptidyl peptidase4 (DPP4)

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