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4 Challenges and future directions 4.1 Safety considerations The safety profile of dual or triple receptor agonists targeting GLP-1, GIP, and GCG receptors in the treatment of MASLD and related metabolic disorders warrants careful evaluation

366 Mice with type 1 diabetes (T1D) exhibit a reduction in bone mineral density (BMD) and compromised microstructural integrity

In SUSTAIN-1 (52 weeks): 3.8 kg (0.5 mg) and 4.6 kg (1.0 mg) vs 1.0 kg with placebo

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