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In over-accumulated WAT, fatty acid by-products, mainly diacylglycerol (DAG), are metabolized through -oxidation in the tricarboxylic acid (TCA) cycle, and under the DAG stimulation of PKC, the NADPH oxidase is directly activated to generate excess ROS [145]

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The two principal incretins , GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), act together with insulin and glucagon to regulate glucose homeostasis and energy balance [1]

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