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Your body processes these medications through different biological pathways, so they don't compete for absorption or metabolism

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This is not always required, but it is a common safety measure to reduce the risk of severe gastrointestinal distress

In SURPASS-2, weight loss with tirzepatide 15 mg was particularly notable, averaging 11.2 kg compared with 5.7 kg for semaglutide 1 mg [12]

Consistent with these findings, peripherally administered CCK induces cFos immunoreactivity in GLP-1-producing neurons of the hindbrain vagal complex of the NTS [354], and surgical vagal deafferentation reduces CCK-induced NTS neuronal cFos activation by approximately 50% [355]