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doi: 10.1001/jamasurg.2016.2317 5 Sanchez-GarridoMABrandtSJClemmensenCMullerTDDiMarchiRDTschopMH

This may also involve satiety promoting and food intake reducing effects by GLP1 via a reduction in the reward value of food by direct action in the mesolimbic reward system (MRS) (Alhadeff et al., 2012)

Lancet 359(9309):824830 Zhang T, Perkins MH, Chang H, Han W, de Araujo IE (2022) An inter-organ neural circuit for appetite suppression

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The study established that mazdutide was superior in glycemic control and provided numerous cardiometabolic benefits, comprising weight loss & improvements in blood lipid levels, liver enzymes, serum uric acid, & blood pressure