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At 72 weeks, the mean percentage change in weight was -20.9% with 15 mg of tirzepatide, as compared with -3.1% with placebo. SURMOUNT-1, per Jastreboff AM et al

Semaglutide has a longer half-life (approximately 7 days) compared to tirzepatide (approximately 5 days), which means the wearing-off effect is less pronounced with semaglutide

Secondary endpoints were also achieved, with 10 mg and 15 mg doses leading to substantial weight loss (up to 63% achieving 20% reduction)

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However, there is an important detail people should understand: There have not yet been large direct head-to-head trials comparing retatrutide and tirzepatide under identical conditions