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doi: 10.1111/dom.12121
N Engl J Med 391: 11931205
Like liraglutide, semaglutide incorporates an Aib substitution at the 8th position in place of Ala, which confers resistance to enzymatic degradation by DPP-4
In patients with type 2 diabetes mellitus, metagenomic analyses reveal that GLP-1RAs induce structural and functional remodeling of gut microbial communities, ameliorating dysbiosis and improving host metabolic homeostasis (Shang et al., 2021)
