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GLP-1, however, engages the GLP-1R/ERK1/2/HDAC6 axis to modulate downstream transcriptional activity, it lowers intracellular ROS, reduces Akt and ERK1/2 phosphorylation, restores HDAC6 expression, and thereby alleviates endothelial dysfunction and excessive autophagy (Zummo et al., 2017)

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We need to treat it like one, just like we treat hypertension or high cholesterol. Two GLP-1 agonists and one dual GIP/GLP-1 agonist are currently FDA-approved to treat obesity

They can also raise your chances of other serious eye problems, like diabetic retinopathy, which can also cause blindness

PASI = Psoriasis Activity Severity Index, DLQI = Dermatology-Related Quality of Life Index, BMI= Body Mass Index VAS = Visual analogue scale (of pain), PsA = Psoriatic arthritis Int = Intervention