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Portillo Canales and colleagues tracked 110 men with obesity - many also with type 2 diabetes - who were being treated with semaglutide, dulaglutide or tirzepatide, the active ingredients in Novo Nordisk's Wegovy and Ozempic or Eli Lilly's Trulicity, Mounjaro, and Zepbound
They also clear the stomach faster even with semaglutide-delayed emptying, because there is less total volume to process
Start with lower doses and increase only if needed, as excessive melatonin can cause grogginess that extends into work hours
One of the biggest concerns after stopping these medications is rebound appetite
