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Primarily, there is a significant deficit of human studies evaluating functional aging outcomes rather than just common metabolic indicators, which should include assessments of cognitive ability, physical performance, and physiological resilience

Consequently, dual GLP-1/glucagon agonists survodutide, and triple GLP-1/GIP/glucagon agonists retatrutide are not spared gastrointestinal adverse events, as glucagon related pro-emetic signaling may offset any potential tolerability benefits from GIP agonism ( The contribution of amylin-based therapies to gastrointestinal adverse events remains less clear

Although these drugs have helped people, GLP-1 drugs are associated with a number of side effects

Its regulatory path was first interrupted by the COVID-19 pandemic

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