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Of note, the dose of GLP-1(2836) used was selected on the basis of its dose response effect on post-IRI LVDP (Supplemental Figure 2)

however, the risk of HFpEF is increasing
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The Asp9 forms a hydrogen bond with Arg370, while Ser8 and Ser11 of Tirzepatide form a network of hydrogen bonds involving the receptor residue Glu288, Arg 289, and Asn290
