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On March 5, Novo Nordisk released the top-line results from this pivotal kidney outcomes trial: Use of semaglutide in patients with diabetic kidney disease reduced the primary outcomea composite of kidney failure, 50% decline in estimated glomerular filtration rate (eGFR), and cardiovascular (CV) or kidney deathby an impressive 24% (Figure 1)

To manage these effects, it is crucial to stick to a nutritionally balanced, reduced-calorie diet where no more than 30% of the calories come from fat, distributed over three main meals

For a lot of people the best drug is just the one theyll actually take, and a daily pill clears a hurdle a weekly shot never did

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They are metabolized in the liver and their conjugated metabolites are excreted mainly by the kidneys[5,25,26]