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Clinical evidence supporting the anti-inflammatory effects of GLP-1 receptor agonists comes primarily from cardiovascular outcome trials and mechanistic studies, though most research has examined standard therapeutic doses rather than specifically low-dose regimens

The macrophage shift is one reason why GLP-1 receptor agonists show benefit across such diverse autoimmune conditions

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Gaspari T, Liu H, Welungoda I, Hu Y, Widdop RE, Knudsen LB, Simpson RW, Dear AE
[27] [28] [32] Exenatide was predicted by Amylin scientist Alain Baron to begin undergoing the Food and Drug Administration's approval process in 2004