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Phase 2 MARITIME data showed 20.0% body weight reduction at 420mg monthly dose over 52 weeks , matching weekly semaglutide and tirzepatide efficacy from a once-monthly format

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A meta-analysis covering over 28,000 patients found that while the overall rate of GI adverse events was similar (approximately 5253% of patients in both groups), serious adverse events occurred somewhat more frequently with higher tirzepatide doses (5.37% at 1015 mg) compared to semaglutide (2.8%)