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It eliminates the cardiovascular burden of adding stimulants and is far safer for long-term use

GLP-1s are FDA-approved as an adjunct to nutrition and lifestyle therapy

[50] A prospective cohort study found the association between habitual snoring and MASLD development to be significant, and the trend was noted to be most prominent in lean individuals

NICE recommends continuing metformin when adding a GLP-1 receptor agonist like semaglutide, as the combination addresses multiple aspects of metabolic dysfunction without significantly increasing hypoglycaemia risk when used alone

Real-time PCR was performed using the QuantStudio 3 real-time PCR system (Invitrogen) and specific primers (Table 1