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Abstract Metabolic-dysfunction-associated fatty liver disease (MAFLD) or metabolic-dysfunction-associated steatotic liver disease (MASLD) has been recognised as one of the most important aetiologies of chronic liver disease and also a marker of high risk for atherosclerotic cardiovascular disease (ASCVD) in patients with or without diabetes

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Individuals can lose as much as 20 to 25% fat in the treated area

In both premises, BBB plays a key role either by representing a potential therapeutic target or a therapeutic vehicle