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The key mechanisms are: Sustained appetite suppression and reduced caloric intake Reduced dietary variety and food volume Delayed gastric emptying Gastrointestinal side effects Rapid weight loss and lean mass reduction Potential alterations in gut microbiota Each pathway contributes differently

The GLP-1R is a class B1 G-protein coupled receptor that predominately couples to a G s subunit leading to the activation of adenylyl cyclase (Kirkpatrick et al., 2012

doi: 10.1111/j.1463-1326.2007.00744.x

This differs fundamentally from traditional dieting, where the same calorie reduction triggers intense cravings and hunger

GLP-1RA were initially developed to treat type 2 diabetes patients, in whom the effects upon glycemia and, moreover, weight loss, especially with long-acting GLP-1RA, were evident