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The magnitude varies significantly between individuals: STEP 4 Trial : Participants who stopped semaglutide after 20 weeks regained approximately 7% body weight over next 48 weeks (compared to losing an additional 8% who continued medication) Real-World Studies : Variable outcomes
[DOI] [PMC free article] [PubMed] [Google Scholar] [33].Brown J, Grzeskowiak L, Williamson K, Downie MR, Crowther CA
This pattern supports natural appetite suppression without the dehydration that can worsen side effects like dizziness or fatigue
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The vagal nerve may also be involved (96) and somatostatin exerts a strong inhibitory influence (47)
