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Gastrointestinal adverse effects are among the most commonly reported challenges with GLP-1 medications, with frequency varying by product, dose and indication

Also, this label update featured a precaution against prescribing Wegovy to patients with severe gastroparesis

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2.2.2 Pyroptosis Activation of the NLRP3 inflammasome is a critical trigger of pyroptosis, leading to gasdermin-mediated membrane pore formation and excessive release of pro-inflammatory cytokines such as IL-1 and IL-18