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As early as 1906 Benjamin Moore (figure 8) and his colleagues at the University of Liverpool had postulated that the duodenum produced a hormone that helped to activate internal secretions in the pancreas

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However, despite the anti-diabetic and anti-obesity functions, of these dual and triple agonists, the long-term safety, cardiovascular, and renal benefits of these multi-target therapies need further validation

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Semaglutide with B12 is a common combination, and the rationale extends to retatrutide