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Altschul stated in the preface to his 1954 book: Because the great majority of heart diseases is caused by coronary thrombosis, which is a lesion of the vessels supplying the heart proper, we may as well cancel the first word in cardiovascular and conclude that, in North America most people who die a natural death succumb to a vascular disease

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Additionally, preclinical animal models provide mechanistic insights but may not fully translate to human physiology, particularly in conditions such as osteoporosis, obesity-related bone changes, and joint infections