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Early studies showed that people on GLP-1s lost quite a bit of lean mass, which some took to mean the loss of muscle

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Researchers found that people taking weekly GLP-1 medications, including tirzepatide, were more likely to still have food in their stomachs than people who werent taking these medications

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Summary: The optimal timing for GLP-1 medications depends on the specific formulation: once-weekly preparations can be taken at any time of day, whilst oral semaglutide must be taken on an empty stomach in the morning
