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Rare genetic loss of myostatin produces unusually muscular animals and humans, which made the pathway an obvious drug target
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The implications are significant: these results raise the possibility that semaglutide may have insufficient central target engagement at the doses used, that the pharmacodynamic effect on AD-relevant pathways may be inadequate, or that targeting metabolic and inflammatory pathways may represent a fundamental limitation when applied to established amyloid-driven Alzheimers disease

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doi: 10.1053/j.gastro.2015.04.005 96 LeeJHongS-WRheeE-JLeeW-Y
